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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PPM1D, NT (Protein Phosphatase 1D, Protein Phosphatase 2C delta Isoform, PP2C-delta, p53-induced Protein Phosphatase 1, Protein Phosphatase Magnesium-dependent 1 delta, WIP1)

Anti -PPM1D, NT (Protein Phosphatase 1D, Protein Phosphatase 2C delta Isoform, PP2C-delta,
p53-induced Protein Phosphatase 1, Protein Phosphatase Magnesium-dependent 1 delta, WIP1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E IH
PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The gene for this protein is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Catalog #P9107-19C
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PABS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide selected from the N-terminal region of human PPM1D (KLH).
SpecificityRecognizes human PPM1D.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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