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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PP2A-Bí (B56) (protein phosphatase 2A Activator, regulatory subunit 4, PPP2R4 Phosphotyrosyl Phosphatase Activator, PP2A, PP2A, Subunit B', PR53 Isoform, PR53, PTPA, Serine/threonine-protein Phosphatase 2A Regulatory Subunit B')

Anti -PP2A-Bí (B56) (protein phosphatase 2A Activator, regulatory subunit 4, PPP2R4
Phosphotyrosyl Phosphatase Activator, PP2A, PP2A, Subunit B', PR53 Isoform, PR53, PTPA,
Serine/threonine-protein Phosphatase 2A Regulatory Subunit B')

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
PP2A is a heterotrimeric type 2 Ser/Thr phosphatase, composed of a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B'/PR61, and B''/PR72 . The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variants derived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals. PTPA is a member of the B' family that is required for activation of PP2A by an undefined mechanism. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades.
Catalog #P9107-34V
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as liquid in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to C-GSLLPIHPVTSG, from the C-Terminus of human Ppp2r4/Pp2a (NP_821068.1; NP_066954.2; NP_821070.1).
SpecificityRecognizes human Ppp2r4/Pp2a. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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