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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PP5 (protein phosphatase 5, catalytic subunit, FLJ36922, PP5, PPP5, PPT, PP-T, Protein phosphatase T, Serine/threonine-protein Phosphatase 5)

Anti -PP5 (protein phosphatase 5, catalytic subunit, FLJ36922, PP5, PPP5, PPT, PP-T,
Protein phosphatase T, Serine/threonine-protein Phosphatase 5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IH
Protein phosphatase 5 (PP5) is a novel human protein serine/threonine phosphatase of molecular weight of 58kD. It is made up of a C-terminal phosphatase catalytic domain and an N-terminal domain, which has four repeats of 34 amino acids, three of which are tandemly arranged. The phosphatase domain contains all of the invariant motifs of the PP1/PP2A/PP2B gene family. However, it is not closely related to any other known member of this family of phosphatases. Thus it makes up a new subfamily of phosphatases. PP5 expressed in bacteria has been shown to dephosphorylate serine residues in proteins and is more sensitive than PP1 to the tumor promoter okadaic acid. PP5 appears to be localized to the nucleus where it is thought to play a roll in the regulation of RNA biogenesis and mitosis as part of a signaling pathway regulating cell cycle progression.
Catalog #P9107-55A
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunoprecipitation (paraffin): 1:100
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat Cell Lysate, A549 and MCF-7 cell lysates.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.08% sodium azide.
PurityPurified
ImmunogenSynthetic peptide derived from the human protein phosphatase 5. Cellular Localization
SpecificityRecognizes human protein phosphatase 5. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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