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You are here:Home » Antibodies » Abs to Serum Proteins » Anti -Protein S (PROS1, PROS, Vitamin K dependent protein S)

Anti -Protein S (PROS1, PROS, Vitamin K dependent protein S)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified B FC
Human Protein S (PS) is a vitamin K–dependent plasma glycoprotein with a molecular weight of ~70kD. In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)–like domains, and a sex hormone–binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain. Monoclonal antibody allows specific detection of cells carrying PS by flow cytometry.
Catalog #P9108-05A
ApplicationsSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionsFlow Cytometry: 1:50
Western Blot: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No9G261
HostRat
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
SpecificityRecognizes human Protein S at ~70kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPS


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