Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications Polyclonal Goat Purified E Gel

Protein S is a vitamin K-dependent, potent neutral anticoagulant plasma glycoprotein. Protein S has a molecular weight of approximately 70kD and concists of a single polypeptide chain. The concentration of protein S in human plasma is 25ug/ml, with a half-life of approximately two days. About 40% of Protein S in plasma is in a free form, whereas 60% is complexed with C4b-binding Protein (C4BP). Only the free Protein S functions as a cofactor to antigen presenting cells (APC) in the APC-dependent degradation of Factor Va and Factor VIIIa.
Protein S is thought to function in both the coagulation and complement cascades. It has been suggested that g-carboxyglutamic acid (gla) dependent binding of protein S to negatively charged phospholipids may function to concentrate C4BP at cell surfaces following injury.
The domain structure of Protein S is similar to that of the other vitamin K-dependent coagulation factors with the exception that Protein S does not possess the catalytic triad. Protein S is a single chain protein containing 10 gla residues in the NH2-terminal domain and 4 epidermal growth factor (EGF) domains.
Catalog #	P9108-06
Applications	Suitable for use ELISA and Immunoelectrophoresis. Other applications not tested.
Recommended Dilutions
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Source	Human
Concentration	~5mg/ml
Form	Supplied in 10mM HEPES, pH7.4, 150mM sodium chloride, 50% glycerol.
Purity	Purified by caprylic acid and ammonium sulfate precipitations, and solid phase adsorption to remove unwanted crossreactivity.
Immunogen	Human Protein S (PS) purified from plasma.
Specificity	Recognizes human Protein S as demonstrated by immunoelectrophoresis and ELISA. Species crossreactivity: porcine and canine.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.