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You are here:Home » Molecular Biology » MB-Translation Initiation Factors » Protein Synthesis Initiation Factor 2a (pS51), Positive and Negative Control Peptides (eIF 2a, Eukaryotic Translation Initiation Factor )

Protein Synthesis Initiation Factor 2a (pS51), Positive and Negative Control Peptides (eIF
2a, Eukaryotic Translation Initiation Factor )

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Specifications

36kD protein ubiquitously expressed in many cell types. The eIF-2 protein, which is composed of three subunits (a, b and g), is one of the key molecules in the initiation of translation. The phosphorylation of eIF-2a is an important regulatory process in protein synthesis. In mammalian cells, eIF-2a is phosphorylated at serine 51 by at least two kinases: the haem-controlled repressor (HCR) and the interferon inducible double stranded RNA-dependent protein kinase (PKR). Phosphorylation of eIF-2a blocks the GDP-GTP exchange activity of eIF-2b, resulting in the suppression of protein synthesis.
P9108-48A1:
Protein Synthesis Initiation Factor 2a (pS51), Positive Control Peptide
Catalog #P9108-48A
SourceSynthetic peptide
MW~1591D
Purity~90% by HPLC.
FormSupplied as a white to off-white lyophilized powder.
AA SequenceH-Ile-Leu-Leu-Ser-Glu-Leu-{pSer}-Arg-Arg-Arg-Ile-Arg-OH
P9108-48A2Protein Synthesis Initiation Factor 2a (pS51), Negative Control Peptide
SourceSynthetic peptide
MW~1512D
Purity~90% by HPLC.
FormSupplied as a white to off-white lyophilized powder.
AA SequenceH-Ile-Leu-Leu-Ser-Glu-Leu-Ser-Arg-Arg-Arg-Ile-Arg-OH
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight1592/1512D
Purity~90% by HPLC and MS analysis
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesILLSELpSRRRIR ILLSELSRRRIR


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