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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PTP1B (Tyrosine-protein Phosphatase Non-receptor Type 1, Protein-tyrosine Phosphatase 1B, PTP-1B, PTPN1, PTP1B)

Anti -PTP1B (Tyrosine-protein Phosphatase Non-receptor Type 1, Protein-tyrosine
Phosphatase 1B, PTP-1B, PTPN1, PTP1B)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites E B
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
Catalog #P9109-03C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10i65
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, 0.09% sodium azide.
PurityAscites
ImmunogenRecombinant protein human PTP1b.
SpecificityRecognizes human PTP1b. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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