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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -Protein Tyrosine Phosphatase, STEP61/46 (Ser221/Ser49), Striatum-enriched protein-tyrosine phosphatase (STEP) isoform 61

Anti -Protein Tyrosine Phosphatase, STEP61/46 (Ser221/Ser49), Striatum-enriched
protein-tyrosine phosphatase (STEP) isoform 61


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Striatum-enriched protein-tyrosine phosphatase (STEP) isoforms 61 and 46 are two of the many splice variants for STEP, a protein belonging to the protein-tyrosine phosphatase family and containing a single tyrosine-protein phosphatase domain. STEP61 is membrane-associated, where as STEP46 is cytosolic. STEP61 also differs in that it contains a sequence of 172 amino acids with structural motifs not found in STEP46. Both isoforms are phosphorylated on serine residues, although STEP61 is mainly phosphorylated at Ser160 and Ser221, while STEP46 is phosphorylated at Ser49. STEP is thought to have a critical role in regulating dopamine efficacy on striatial medium spiny neurons, neurotransmission through the NMDAR pathway, and AMPA receptor endocytosis.
Catalog #P9109-27Z
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1ug/ml detects STEP61/46 on 10ug of mouse brain tissue lysate.
Immunohistochemistry: 1:600 detects phosphorylated STEP61/46 in caudata putamen region of adult human brain tissue.
Optimal dilutions to be determined by the researcher.
Positive ControlMouse brain tissue lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150 mM sodium chloride, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to mouse STEP61/46 phosphorylated at Ser221/Ser49 (KLH). Epitope: Phosphorylated Ser221/Ser49
SpecificityRecognizes mouse STEP61. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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