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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PTPN11 (Tyr584) (Tyrosine-protein Phosphatase Non-receptor Type 11, Protein-tyrosine Phosphatase 2C, PTP-2C, Protein-tyrosine Phosphatase 1D, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2, SHPTP2, PTP2C)

Anti -PTPN11 (Tyr584) (Tyrosine-protein Phosphatase Non-receptor Type 11, Protein-tyrosine
Phosphatase 2C, PTP-2C, Protein-tyrosine Phosphatase 1D, PTP-1D, SH-PTP3, SH-PTP2, SHP-2,
Shp2, SHPTP2, PTP2C)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
SHP2, also known as PTPN11, is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in the gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Catalog #P9109-29C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to a region between corresponding to a portion of amino acids within aa565-594, surrounding Y584 of human SHP2, conjugated to KLH.
Species Sequence HomologyMouse and rat.
Cellular LocalizationCytoplasm
SpecificityRecognizes human SHP2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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