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You are here:Home » Molecular Biology » MB-Enzymes, Synthase » 6-Pyruvoyltetrahydropterin Synthase, PTS, Recombinant, Human (PTPS, PTP synthase)

6-Pyruvoyltetrahydropterin Synthase, PTS, Recombinant, Human (PTPS, PTP synthase)

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Specifications

6-Pyruvoyltetrahydropterin synthase (PTS), also known as PTPS, belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.
Catalog #P9109-48E
Recombinant human PTS, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Endotoxin 1EU/1ug (LAL)
Amino Acid SequenceMGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE
Molecular Weight 18.5kD (165aa)
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight18.5kD
SourceE.coli
Purity~90% by SDS-PAGE, fused to His-tag at N-terminus.
Concentration~1mg/ml
FormSupplied as a liquid in 20mM Tris-HCl buffer, pH8.0,1mM DTT, 20% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPTPS, PTP synthase


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