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Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1) (Ser380/Thr382/383)
Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1)
(Ser380/Thr382/383)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
E B |
|
| PTEN (phosphatase and tensin homologue deleted on chromosome ten), also refered to as MMAC (mutated in multiple advanced cancers), phosphatase is a tumor suppressor implicated in a wide variety of human cancers (1). PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase (2). The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K) (3). PTEN is a major negative regulator of the PI3K/Akt signaling pathway (1,4–5). PTEN possesses a carboxy-terminal noncatalytic regulatory domain containing three phosphorylation sites (Ser380, Thr382 and Thr383), which regulates its stability and may play an important role in control of its biological activity (6,7). PTEN also regulates p53 protein levels and activity (8) and is involved in G protein coupled signaling during chemotaxis (9,10). | | | Catalog # | P9182-01E | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western blot 1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Clone No | 7H54 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol and less than 0.02% sodium azide. | | Purity | Supernatant | | Immunogen | Synthetic phospho-peptide (KLH-coupled) corresponding to residues around Ser380, Thr382 and Thr383 of human PTEN. | | Specificity | Detects endogenous levels of PTEN only when phosphorylated at serine 380, threonine 382 and threonine 383. Species Crossreactivity: Human, monkey, mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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