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You are here:Home » Antibodies » Antibodies-Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1) (Alexa Fluor®488)

Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1) (Alexa


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant FC
PTEN (phosphatase and tensin homologue deleted on chromosome ten), also refered to as MMAC (mutated in multiple advanced cancers) phosphatase, is a tumor suppressor implicated in a wide variety of human cancers (1). PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase (2). The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3-kinase (PI3K) (3). PTEN is a major negative regulator of the PI3K/Akt signaling pathway (1,4–5). PTEN possesses a carboxy-terminal noncatalytic regulatory domain containing three phosphorylation sites (Ser380, Thr382 and Thr383), which regulates its stability and may play an important role in control of its biological activity (6,7). PTEN also regulates p53 protein levels and activity (8) and is involved in G protein coupled signaling during chemotaxis (9,10). Specificity/Sensitivity: PTEN (138G6) Rabbit mAb (Alexa Fluor® 488 Conjugate) detects endogenous levels of total PTEN protein.
Catalog #P9182-01F
ApplicationsSuitable for use in FLISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Note: We do not recommend adding glycerol as a cryopreservative.
Clone TypeMonoclonal
Clone No7H55
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, 2 mg/ml BSA. Labeled with Alexa Fluor® 488.
ImmunogenSynthetic peptide (KLH-coupled) derived from the carboxy-terminal sequence of human PTEN.
SpecificityRecognizes human, monkey, mouse and rat PTEN protein and will also recognize PTEN in these species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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