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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380) (MMAC1, Phosphatase and Tensin, TEP1)

Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380) (MMAC1, Phosphatase and
Tensin, TEP1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC
The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, in conjunction with FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation, creating PI(3,4,5)P3. In cells lacking PTEN, there are elevated levels of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
Catalog #P9182-01N
ApplicationsSuitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry.
Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Immunocytochemistry: 1:100-250
Immunohistochemistry (Paraffin): 1:100-250
Optimal dilutions to be determined by the researcher.
Positive ControlNIH/3T3 cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No10F656
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid 0.1% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues near Ser380 of human PTEN.
SpecificityRecognizes human phospho-PTEN (Ser380). Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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