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You are here:Home » Antibodies » Antibodies-Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1)

Anti -PTEN Tumor Suppressor Protein (MMAC1, Phosphatase and Tensin, TEP1)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
PTEN (also know as MMAC1) was recently identified as a candidate tumor suppressor gene. Deletions or mutations within the PTEN gene have been observed in a variety of tumor cell lines and cancer cell types. Based on PTEN’s structural features, the protein was originally thought to be a protein tyrosine phosphatase. However, recent evidence indicates that PTEN is actually a lipid phosphatase rather that a protein tyrosine phosphatase. In fact, the target substrate for PTEN is phosphatidylinositol-3,4,5-triphosphate (Ptd-Ins(3,4,5)P3). Ptd-Ins(3,4,5)P3 is a critical second messenger involved in cell signaling and growth control. Ptd-Ins(3,4,5)P3 is produced by phosphorylation of Ptd-Ins(4,5)P2 by PI 3-kinase in response to stimulation by various ligands. By dephosphorylating Ptd-Ins(3,4,5)P3, PTEN functions to “turn off” the Ptd-Ins(3,4,5)P3 pathway and thereby suppress cellular proliferation.
Catalog #P9182-02
ApplicationsSuitable for use in ELISA, Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.1–1.0ug/ml
Western Blot: 1–3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA 22 amino acid synthetic peptide derived form the carboxy-terminus of the human PTEN protein.
SpecificityDetects the ~55kD PTEN protein. Will recognize both endogenous PTEN and transfected, overexpressed PTEN. Species crossreactivity: Human and mouse PTEN proteins. Predicted to crossreact with canine based on sequence homology and differs by only one amino acid from the rat PTEN protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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