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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN, phosphorylated (Ser380/Thr/382/Thr383) (PTEN Tumor Suppressor Protein, Phosphatase and Tensin Homolog, MMAC1, TEP1, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase PTEN, Mutated in Multiple Advanced Ca

Anti -PTEN, phosphorylated (Ser380/Thr/382/Thr383) (PTEN Tumor Suppressor Protein,
Phosphatase and Tensin Homolog, MMAC1, TEP1, Phosphatidylinositol-3,4,5-trisphosphate
3-phosphatase and Dual-specificity Protein Phosphatase PTEN, Mutated in Multiple Advanced
Ca

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IF
PTEN is a tumor suppressor gene implicated in a wide variety of human cancers. PTEN encodes the 403aa polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3 kinase (PI3K). PTEN is a major negative regulator of the PI3K/Akt signaling pathway. PTEN possesses a C-terminal noncatalytic regulatory domain that contains three phosphorylation sites (Ser380, Thr382, and Thr383), which regulates its stability and could play an important role in control of its biological activity.
Catalog #P9182-02E
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:100-1:200
Western Blot: 1:500-1:1,000
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human PTEN around the phosphorylation site of serine 380 and threonine 382/383 (R-Y-SP-D-TP-TP-D-S).
SpecificityRecognizes human PTEN Tumor Suppressor Protein when phosphorylated at Ser380/Thr/382/Thr383. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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