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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380) (Phosphatase and Tensin Homolog, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Dual-specificity Protein Phosphatase PTEN, PTEN1, 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, Mutated in Multi

Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380) (Phosphatase and Tensin
Homolog, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Dual-specificity
Protein Phosphatase PTEN, PTEN1, 10q23del, BZS, DEC, GLM2, MGC11227, MHAM, Mutated in
Multi

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT:PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1:Grb2:Sos complex. Human PTEN gene is mapped to chromosome 10q23.3.
Catalog #P9182-02K
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human PTEN around the phosphorylation site of serine 380 (R-Y-SP-D-T).
SpecificityRecognizes human PTEN when phosphorylated at Ser380. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.1.3.16, EC=3.1.3.48, EC=3.1.3.67


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