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Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser370) (MMAC1, Phosphatase and Tensin, TEP1)
Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser370) (MMAC1, Phosphatase and
Tensin, TEP1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| PTEN (Phosphatase and tensin analog) is a ~58kD tumor suppressor protein that plays a key role in cell migration, survival and apoptosis by negatively regulating phosphoproteins in the Akt/PI3Kinase pathway. The non-catalytic regulatory carboxyl terminus of PTEN contains multiple phosphorylation sites, including serine 370, which is constitutively phosphorylated by CK2. Phosphorylation of serines 370 and 385 primes PTEN for additional phosphorylation of nearby residues and plays a critical role in maintaining its stability. | | | Catalog # | P9182-14 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | 3T3-L1 adipocytes; NIH-3T3 cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic phosphopeptide derived from a region of human PTEN that contains serine 370. | | Specificity | Recognizes mouse PTEN wnen phosphorylated at Ser370. Species sequence homology: Human and rat PTEN (100%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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