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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser385) (MMAC1, Phosphatase and Tensin, TEP1)

Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser385) (MMAC1, Phosphatase and
Tensin, TEP1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
PTEN (Phosphatase and tensin homolog deleted on chromosome 10) is a ~58kD lipid phosphatase and tumor suppressor protein that is frequently mutated in tumor cells. It plays a key role in cell migration, survival and apoptosis by negatively regulating phosphoproteins in the Akt/PI3Kinase pathway and is involved in Toll-like receptor 4 (TLR) and Fc-gamma-mediated macrophage inflammatory responses. The non-catalytic regulatory carboxyl terminus of PTEN contains multiple phosphorylation sites including two CK2 sites (serines 370 and 385) and MAGI-2 sites (threonines 382 and 383). Phosphorylation of serine 370 and 385 primes PTEN for additional phosphorylation of nearby residues while phosphorylation of serine 380 and threonines 382 and 385 plays a critical role in regulating PTEN stability.
Catalog #P9182-14C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlHEK293 cells overexpressing WT PTEN
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide derived from a region of human PTEN that contains serine 385.
SpecificityRecognizes human PTEN when phosphorylated at Ser385. Species sequence homology: Mouse and rat PTEN (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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