Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380, Thr382, Thr383, Ser385)
(MMAC1, Phosphatase and Tensin, TEP1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B |
|
| The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes PI(3,4,5)P3, the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation. In cells lacking PTEN, there is an elevated level of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration. | | | Catalog # | P9182-15G | | Applications | | | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:5000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H267 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to amino acids surrounding phosphorylated Ser380 of human PTEN. Epitope: Phosphorylated Ser380 (CT). | | Specificity | Recognizes PTEN when phosphorylated on Ser380. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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