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You are here:Home » Antibodies » Abs to Tumor Suppressors » Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380, Thr382, Thr383, Ser385) (MMAC1, Phosphatase and Tensin, TEP1)

Anti -PTEN Tumor Suppressor Protein, phosphorylated (Ser380, Thr382, Thr383, Ser385)
(MMAC1, Phosphatase and Tensin, TEP1)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes PI(3,4,5)P3, the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation. In cells lacking PTEN, there is an elevated level of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.
Catalog #P9182-15G
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:5000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H267
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to amino acids surrounding phosphorylated Ser380 of human PTEN. Epitope: Phosphorylated Ser380 (CT).
SpecificityRecognizes PTEN when phosphorylated on Ser380. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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