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You are here:Home » Antibodies » Abs to Disease Markers » Anti -PTEN Tumor Suppressor Protein (Phosphatase and Tensin Homolog, Bannayan Zonana Syndrome, BZS, MGC11227, Multiple Hamartoma (Cowden Syndrome), MHAM, Mutated in Mutiple Advanced Cancers 1, MMAC1, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Du

Anti -PTEN Tumor Suppressor Protein (Phosphatase and Tensin Homolog, Bannayan Zonana
Syndrome, BZS, MGC11227, Multiple Hamartoma (Cowden Syndrome), MHAM, Mutated in Mutiple
Advanced Cancers 1, MMAC1, Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and Du

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The PTEN tumor suppressor gene acts as a phospholipid phosphatase. Under normal growth conditions, stimulatory signals from the insulin receptor activate the enzyme PI3-K, which phosphorylates phosphotidylinositol 4,5-bisphosphate (PIP2) to generate phosphotidylinositol 3,4,5-triphosphate (PIP3), a lipid molecule. Downstream, PIP3 activates several effectors, including the proto-oncogene product PKB/Akt. The role of PTEN is to dephosphorylate PIP3, acting as a negative control on PKB/Akt activation. If a mutation in PTEN causes it unable to carry out its phosphatase function, PIP3 can no longer be deactivated, so it continues to propagate its signal downstream. This may result in the continued activation of PKB/Akt, which, in combination with other factors, could lead to increased cell growth and possible tumor development.
Catalog #P9182-16E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormAs reported
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide, which represented a portion of the C-terminus of human phosphatase and tensin homolog (LocusLink ID 5728).
SpecificitySpecific for human PTEN protein. Other species have not been tested. Reactivity with mouse and Xenopus laevis is likely due to the conservation of sequence between the immunogen and these species orthologs.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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