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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -PTK7, NT (Tyrosine-Protein Kinase-Like 7, Colon Carcinoma Kinase 4, CCK-4, Protein-Tyrosine Kinase 7, CCK4)

Anti -PTK7, NT (Tyrosine-Protein Kinase-Like 7, Colon Carcinoma Kinase 4, CCK-4,
Protein-Tyrosine Kinase 7, CCK4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Protein tyrosine kinase-like 7 (PTK7) is a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle.
Catalog #P9182-56B
PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates.
Studies also suggest that PTK7 may be involved in the tumor progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumor progression.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA 15aa peptide located near the N-terminal region of human PTK7.
SpecificityRecognizes human Protein tyrosine kinase-like 7 at ~86kD in colon tissue lysates. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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