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You are here:Home » Antibodies » Antibodies-Tyrosine Kinases » Anti -PTK7, NT (Tyrosine-Protein Kinase-Like 7, Colon Carcinoma Kinase 4, CCK-4, Protein-Tyrosine Kinase 7, CCK4)

Anti -PTK7, NT (Tyrosine-Protein Kinase-Like 7, Colon Carcinoma Kinase 4, CCK-4,
Protein-Tyrosine Kinase 7, CCK4)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Protein tyrosine kinase-like 7 (PTK7) is a member of the receptor tyrosine kinase family, otherwise known as Colon Carcinoma Kinase 4 (CCK4). PTK7 is highly expressed in the kidney, liver, lung, pancreas and melanocytes with weaker expression being detected in the thyroid gland, ovaries, brain, heart and skeletal muscle.
Catalog #P9182-56B
PTK7 may play a role in embryonic development. It is thought to function as a cell adhesion molecule and as a novel regulator of the planar cell polarity (PCP) pathway in vertebrates.
Studies also suggest that PTK7 may be involved in the tumor progression. A loss of PTK7 expression has been observed in melanoma cell lines, whereas increased levels of PTK7 have been detected in high-throughput acute myeloid leukemia samples. In addition, PTK7 is not expressed in normal colon but has been detected in colon carcinomas and as such is a potential marker for tumor progression.
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenA 15aa peptide located near the N-terminal region of human PTK7.
SpecificityRecognizes human Protein tyrosine kinase-like 7 at ~86kD in colon tissue lysates. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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