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You are here:Home » Antibodies » Abs to Splicing Factors » Anti -PUF60 (60kD Poly(U)-binding-splicing Factor, Fuse-binding Protein-interacting Repressor, FBP-interacting Repressor, Poly-U Binding Splicing Factor PUF60, Pyrimidine Tract-binding Splicing Factor, Ro Ribonucleoprotein-binding Protein 1, Ro-binding Protein

Anti -PUF60 (60kD Poly(U)-binding-splicing Factor, Fuse-binding Protein-interacting
Repressor, FBP-interacting Repressor, Poly-U Binding Splicing Factor PUF60, Pyrimidine
Tract-binding Splicing Factor, Ro Ribonucleoprotein-binding Protein 1, Ro-binding Protein

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
PUF60 is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. PUF60 also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. PUF60 gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for PUF60 gene.
Catalog #P9191-25
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Cellular Localization Cytoplasmic
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in TBS, pH 7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: YDQERFDNSDLSA, representing the C-terminus of the human protein (530-542), according to NP_055096; NP_510965.
SpecificityRecognizes both reported human isoforms of PUF60. Expected to crossreact with Mouse (100% identity with immunogen), Rat (100% identity with immunogen), Orangutan (100% identity with immunogen) and porcine (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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