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Puromycin Dihydrochloride (Achromycin, Stillomycin, Stylomycin, Antibiotic CL 13900, Antibiotic 3123L, Antibiotic P638, Bacterenomycin) (Powder)
Puromycin Dihydrochloride (Achromycin, Stillomycin, Stylomycin, Antibiotic CL 13900,
Antibiotic 3123L, Antibiotic P638, Bacterenomycin) (Powder)
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| A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2-5ug/ml, while cells in suspension are sensitive to concentrations as low as 0.5-2ug/ml. | | | Catalog # | P9200-01A | | Solubility | H2O (~50mg/ml) | | Molecular Weight | ~544.43 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 58-58-2 | | Molecular Formula | C H N O · 2HCl | | Molecular Weight | ~544.43 | | Purity | ~98% (HPLC) | | Form | Supplied as a white to off-white solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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