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You are here:Home » Biochemicals » Biochem-Antibiotics » Puromycin Dihydrochloride (Achromycin, Stillomycin, Stylomycin, Antibiotic CL 13900, Antibiotic 3123L, Antibiotic P638, Bacterenomycin) (Powder)

Puromycin Dihydrochloride (Achromycin, Stillomycin, Stylomycin, Antibiotic CL 13900,
Antibiotic 3123L, Antibiotic P638, Bacterenomycin) (Powder)

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Specifications

A nucleoside antibiotic. It inhibits protein synthesis by disrupting peptide transfer on ribosomes causing premature chain termination during translation. It is a potent translational inhibitor in both prokaryotic and eukaryotic cells. Resistance to puromycin is conferred by the puromycin N-acetyl-transferase gene (pac) from Streptomyces. Puromycin has a fast mode of action, causing rapid cell death at low antibiotic concentrations. Adherent mammalian cells are sensitive to concentrations of 2-5ug/ml, while cells in suspension are sensitive to concentrations as low as 0.5-2ug/ml.
Catalog #P9200-01A
SolubilityH2O (~50mg/ml)
Molecular Weight~544.43
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number58-58-2
Molecular FormulaC H N O 2HCl
Molecular Weight~544.43
Purity~98% (HPLC)
FormSupplied as a white to off-white solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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