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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Pyk2 (Protein-tyrosine Kinase 2-beta, PKB, PTK2B, Calcium-dependent Tyrosine Kinase, CADTK, Cell Adhesion Kinase beta, CAK-beta, CAKB, Focal Adhesion Kinase 2, FADK 2, FADK2, FAK2, Proline-rich Tyrosine Kinase 2, PTK, Related Adhesion Focal Tyrosine Kinas

Anti -Pyk2 (Protein-tyrosine Kinase 2-beta, PKB, PTK2B, Calcium-dependent Tyrosine Kinase,
CADTK, Cell Adhesion Kinase beta, CAK-beta, CAKB, Focal Adhesion Kinase 2, FADK 2, FADK2,
FAK2, Proline-rich Tyrosine Kinase 2, PTK, Related Adhesion Focal Tyrosine Kinas

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Pyk2, has been shown to function in signal transduction through G protein-coupled receptors in neuronal cells, as well as in signaling via the T-cell receptor. Pyk2 is structurally related to focal adhesion kinase (FAK) and contains the canonical binding site (Y881) for the SH2 domain of Grb2 and the interacting site for the SH2 domain of Src. It is one of the signaling mediators critical for the G protein-coupled receptor to the MAPK pathway. Pyk2 is associated with, and tyrosine phosphorylated by, Jak3 in the pathway of interleukin-2 (IL-2) receptor signaling. It is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Pyk2 is highly expressed in the central nervous system.
Catalog #P9400-01C
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human Pyk2 around the phosphorylation site of tyrosine 402 (D-I-YP-A-E).
SpecificityRecognizes human Pyk2. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPTK2B Protein Tyrosine Kinase 2 beta, EC=2.7.10.2


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