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You are here:Home » Antibodies » Abs to Tyrosine Kinases » Anti -Pyk2a, phosphorylated (Tyr402) (CAKbeta, cdk-activating Protein Kinase beta)

Anti -Pyk2a, phosphorylated (Tyr402) (CAKbeta, cdk-activating Protein Kinase beta)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Protein tyrosine kinase Pyk2, also called CAKbeta, RAFTK and CADTK, is a nonreceptor tyrosine kinase structurally related to focal adhesion kinase (FAK) (14). Pyk2 is predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for the G-protein-coupled receptors and MAP kinase signaling pathway. It plays an important role in cell motility such as spreading and migration (57). Pyk2 is tyrosine phosphorylated and activated upon ligation of TCR (8,9). Phosphorylated tyrosine 402 of Pyk2 is required for the phosphorylation of other tyrosines on Pyk2 and provides a binding site for Fyn SH2 in the Tcell activation (10).
Catalog #P9400-02
ApplicationsSuitable for use in Western Blotting, Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunoprecipitation: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100 ug/ml BSA, 50% glycerol.
PurityPurified by protein A and peptide affinity chromatography.
ImmunogenSynthetic phosphopeptide (KLH coupled) corresponding to residues surrounding Tyr402 of human Pyk2.
SpecificityDetects endogenous levels of Pyk2 only when phosphorylated at tyrosine 402.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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