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You are here:Home » Antibodies » Abs to Protein Kinase Substrates » Anti -PDHX (Pyruvate Dehydrogenase Protein X Component, Mitochondrial, Dihydrolipoamide Dehydrogenase-binding Protein of Pyruvate Dehydrogenase Complex, Lipoyl-containing Pyruvate Dehydrogenase Complex Component X, E3-binding Protein, E3BP, PDX1)

Anti -PDHX (Pyruvate Dehydrogenase Protein X Component, Mitochondrial, Dihydrolipoamide
Dehydrogenase-binding Protein of Pyruvate Dehydrogenase Complex, Lipoyl-containing
Pyruvate Dehydrogenase Complex Component X, E3-binding Protein, E3BP, PDX1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B IH
PDX1, also known as Pancreas/duodenum homeobox protein 1, is a nuclear protein belonging to the Antp homeobox family and IPF1/XlHbox-8 subfamily with a homeobox DNA-binding domain. It activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription and is particularly involved in glucose-dependent regulation of insulin gene transcription. During development, PDX1 specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. Expression is common in duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Defects in PDX1 are associated with pancreatic agenesis, maturity onset diabetes noninsulin-dependent diabetes mellitus (NIDDM), also known as diabetes mellitus type II, and maturity onset diabetes of the young type 4 (MODY4).
Catalog #P9544-01G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 3ug/ml
Western Blot: 0.1-1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Pancreas lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KSFKANLENPIRLA, from the C-terminus of the protein sequence according to NP_003468.
SpecificityRecognizes human PDHX. Species sequence homology: chimpanzee, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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