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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B IP

Rab7 and Rab9 are members of the Ras superfamily of small Rab GTPases (1). Both proteins are located in late endosomes but exert different functions. Rab7 associates with the RIPL effector protein to control membrane trafficking from early to late endosome and to ly- sosomes (2,3). Rab7 also helps to regulate growth receptor endocytic trafficking and degradation (3,4), and matura- tion of phagosome and autophagic vacuoles (4-6). Rab9 interacts with its effector proteins p40 and TIP47 (7,8) to promote the MPR (mannose 6-phosphate receptors)-associ- ated lysosomal enzyme transport between late endosomes and the trans Golgi network (9,10).
Catalog #	R0008-81
Applications	Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution	Western Blot: 1:1000
	Immunoprecipitation: 1:50
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Concentration	As reported
Form	Supplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
Purity	Purified by peptide affinity chromatography.
Immunogen	Synthetic peptide (KLH-coupled) corresponding to residues surrounding Asn184 of human Rab9.
Specificity	Detects endogenous levels of total Rab9 protein.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.