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Abs to GTPase, Rab, Ras, Rho Proteins
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Anti -Rac1 (Ras-related C3 Botulinum toxin substrate 1, rho family, small GTP binding protein Rac1, Cell migration-inducing gene 5 protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, Ras-related C3 botulinum toxin substrate 1, TC-25) (Agarose)
Anti -Rac1 (Ras-related C3 Botulinum toxin substrate 1, rho family, small GTP binding
protein Rac1, Cell migration-inducing gene 5 protein, MGC111543, MIG5, p21-Rac1, Ras-like
Protein TC25, Ras-related C3 botulinum toxin substrate 1, TC-25) (Agarose)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
IP |
|
| Rac is a member of the Rho family of small GTP-binding proteins, and plays roles in cytoskeletal actin organization as well as transformation. Rac is activated downstream of cdc42, or independently by Ras signaling, and in turn Rac stimulates Rho. Activation of Rac results in the formation of lamellipodia, whereas cdc42 stimulates filopodia formation, and Rho stimulates formation of actin stress fibers. Effectors of the Rac pathway include NADPH Oxidase and the SAPK1/JNK family of kinases. The latter pathway is activated by the PAK kinases, which are direct targets of Rac. | | | Catalog # | R0400-02C | | Applications | Suitable for use in Immunoprecipitation and Immunoaffinity Chromatography methods. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | 9H268 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Ascites. | | Immunogen | Recombinant protein containing the full length human Rac1. Cellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. | | Specificity | Recognizes Rac1 with a strong preference. There is a slight Rac2 cross-reactivity. Species Crossreactivity: human, mouse, rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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