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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Rac1 (Ras-related C3 Botulinum Toxin Substrate 1, Cell Migration-inducing Gene 5 Protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, TC25, TC-25)

Anti -Rac1 (Ras-related C3 Botulinum Toxin Substrate 1, Cell Migration-inducing Gene 5
Protein, MGC111543, MIG5, p21-Rac1, Ras-like Protein TC25, TC25, TC-25)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Rac1 is a member of the Rho family of GTPases, which control multiple cell functions including cell cycle progression, gene expression, apoptosis, actin organization, cell motility, and the invasive potential of human tumor cells. Rho GTPases act as switches, coordinating and integrating multiple pathways. Rac1 is regulated by the extent of binding of GTP. It is activated by guanine nucleotide exchange factors (GEFs) that catalyze exchange of GDP for GTP and inactivated by GTPase-activating proteins (GAPs) that promote GTP hydrolysis. Studies show that Rac1 protein levels get elevated in some tumors and tumor cell lines. Human Rac1 gene is localized on chromosomal region 7p22.
Catalog #R0400-02H
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlA431 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human Rac1 around the phosphorylation site of serine 71 (P-L-SP-Y-P).
SpecificityRecognizes human Rac1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesRas-related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1)


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