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You are here:Home » Biochemicals » Biochem-Antibiotics » Radicicol (Monorden)

Radicicol (Monorden)


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Radicicol is a resorcylic acid lactone produced by several fungal species that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and been shown to inhibit protein tyrosine kinase, induce the differentiation of HL-60 cells into macrophages, block cell cycle at G1 and G2, suppress NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppress the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.
Catalog #R0470
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
CAS Number12772-57-5
Molecular FormulaC18H17ClO6
Molecular Weight364.78
SourceUnidentified fungus
Purity> 99% by HPLC
FormWhite solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesMonorden

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