Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear
Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4,
Ras-related Nuclear Protein, RASL2-8, TC4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport (1). During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation (1,2). In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle (3). | | | Catalog # | R1069-02 | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilution determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol, 0.02% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Polyclonal antibodies are produced by immunizing rabbits with two synthetic peptides (KLH-coupled) corresponding to amino acids surrounding Arg29 and Asn143 of human Ran. | | Specificity | Recognizes endogenous levels of total human Ran protein. Does not cross-react with other small GTPases of the Ras family. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4, Ras-related Nuclear Protein, RASL2-8, TC4) |
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