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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4, Ras-related Nuclear Protein, RASL2-8, TC4)

Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear
Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4,
Ras-related Nuclear Protein, RASL2-8, TC4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Ran is a small GTPase of the Ras family that plays a central role in the spacial and temperal organization of eukaryotic cells. During interphase, Ran-GDP localizes to the cytoplasm and Ran-GTP to the nucleus. This polarized localization of Ran ensures its role in nuclear transport. During mitosis, Ran-GTP is chromatin associated, where it promotes spindle assembly and nuclear envolope formation. In S phase, Ran-GTP associates with and inhibits MCM helicase, ensuring precise chromosomal DNA duplication during the cell cycle.
Catalog #R1069-02
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000. Incubate membrane with 1X TBS, 5% BSA. 0.1% Tween-20 at 4ºC with gentle shaking overnight.
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by Protein A and peptide affinity chromatography.
ImmunogenTwo synthetic peptides corresponding to amino acids surrounding Arg29 and Asn143 of human Ran. Species Sequence Homology: D. melanogaster and Xenopus, 100%
SpecificityRecognizes endogenous levels of total human Ran protein. Does not crossreact with other small GTPases of the Ras family. Species Crossreactivity: mouse, rat, monkey, hamster and bovine
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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