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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4, Ras-related Nuclear Protein, RASL2-8, TC4)

Anti -Ran (Androgen Receptor-associated Protein 24, ARA24, Gsp1, GTP Binding Nuclear
Protein RAN, GTPase Ran, LPS, RAN Member RAS Oncogene Family, Ras-like Protein TC4,
Ras-related Nuclear Protein, RASL2-8, TC4)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IF
Ran is a small GTPase of the Ras superfamily that controls nucleocytoplasmic transport. However, Ran also functions in the absence of a membrane-enclosed nucleus, during cell division. RanGTP acts to promote microtubule nucleation during mitotic spindle assembly and, later during mitosis, is required for NE assembly. For correct spindle and NE assembly on chromatin, it is critical that the RanGTP concentration on or near chromatin is higher than in the surrounding mitotic cytoplasm. Unlike many other regulatory GTPases, Ran is not posttranslationally modified so that it can be targeted to the subcellular compartment where it acts. Rather, RanGTP has been thought to be localized by the differential localization of Ran regulators. During mitosis, the nucleotide exchange factor RCC1, which generates RanGTP, is in part bound to chromatin. This results in the preferential production of RanGTP on the chromatin surface. From there, RanGTP is believed to diffuse only a short distance before either encountering mediators of spindle or NE assembly or, alternatively, being reconverted to RanGDP under the influence.
Catalog #R1069-04
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Cellular Localization Nuclear
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
PurityWhole antisera
ImmunogenRecombinant full length protein (Human) - His-tagged and purified from E. coli.
SpecificitySpecies Crossreactivity: Crossreacts with Human and Xenopus laevis.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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