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You are here:Home » Molecular Biology » Growth Factors-RANK » RANK, Recombinant, Human (Receptor Activator of NFkB)

RANK, Recombinant, Human (Receptor Activator of NFkB)

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Specifications

Human RANK (receptor activator of NF-KappaB), a soluble 20kD protein, comprising the full-length of the TNF-like extracellular domain of RANKL, is a member of the TNFR family, identified as a dentritic cell membrane protein.
Catalog #R1075
Endotoxin 0.1ng/ug (1EU/ug)
ReconstitutionReconstitute with sterile dH2O to a concentration of 0.1-1mg/ml. Solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or -20°C for future use.
Biological ActivityDetermined by its ability to induce osteoclast formation in RAW264.7 cells using a concentration range of 5.0-10.0 ng/ml
The ED50 as determined by the dose-dependent stimulation of IL-8 production by human PBMC (peripheral blood mononuclear cells) is 10ng/ml.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile dH2O, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight20kD
SourceHuman, recombinant expressed in E. coli
Purity98% by SDS-PAGE and HPLC analysis.
FormSupplied as a lyophilized powder in PBS, pH 7.6.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesReceptor activator of NF-KappaB


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