Anti -RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of
NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast
Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor
Superfamily Membe
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IH FC |
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| Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2. | | | Catalog # | R1075-04D | | Applications | Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: Paraffin-embedded sections | | Western Blot: 1-2ug/ml | | Flow Cytometry: Cell surface | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 9C30 | | Host | Mouse | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | A fusion protein containing aa326-616 of human RANK. | | Specificity | Recognizes human RANK. In RAW cells, a band at ~97kD. Recognizes an epitope located between aa330-427 of human RANK. Species Crossreactivity: mouse | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | CD265 Antigen |
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Download Specifications for Anti -RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor Superfamily Membe |
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