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You are here:Home » Antibodies » Abs to RANK » Anti -RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor Superfamily Membe

Anti -RANK (Receptor Activator of NF-kB, Nuclear Factor kappa B, Receptor Activator of
NFkB, Activator of NFkB, CD265, EOF, FEO, mRANK, NFKB Activator, Osteoclast
Differentiation Factor Receptor, ODFR, OFE, PDB2, Tumor Necrosis Factor Receptor
Superfamily Membe

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH FC
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family. RANK ligand (RANKL/TRANCE/ OPGL) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6. Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways. Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2.
Catalog #R1075-04D
ApplicationsSuitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: Paraffin-embedded sections
Western Blot: 1-2ug/ml
Flow Cytometry: Cell surface
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No9C30
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenA fusion protein containing aa326-616 of human RANK.
SpecificityRecognizes human RANK. In RAW cells, a band at ~97kD. Recognizes an epitope located between aa330-427 of human RANK. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCD265 Antigen


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