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Anti -RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand)
Anti -RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IH FC |
|
| TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. TRANCE/RANKL is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis. | | | | | | Applications: | | | Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry (frozen sections). Other applications not tested. | | | Catalog # | R1075-12A | | Recommended Dilution | Western Blot: 4-6ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6D724 | | Host | Mouse | | Source | Mouse | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS with 0.05% sodium azide and 0.05% BSA. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant mouse RANKL (aa 1-317). | | Specificity | Recognizes mouse RANKL. Detects a band of ~40kD by Western blot. Species crossreactivity: human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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