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You are here:Home » Antibodies » Abs to RANK » Anti -RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand)

Anti -RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH
RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand) is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. TRANCE/RANKL is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Catalog #R1075-13
Recommended DilutionsWestern Blot: 1-2ug/ml
Immunohistochemistry: Paraffin sections
Optimal dilutions to be determined by the researcher.
Positive ControlActivated T cells or RAW cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No6D723
HostMouse
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS.
PurityPurified by Protein G affinity chromatography
ImmunogenBacterially expressed fusion protein corresponding to aa1-317 of mouse RANKL.
SpecificityRecognizes mouse RANKL. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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