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You are here:Home » Antibodies » Antibodies-RANK » Anti -RANKL (Receptor Activator of Nuclear Factor kappa B Ligand, Receptor Activator of NFkB Ligand, CD254, hRANKL2, hRANKL-2, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL, sOdf, SOFA, TNF-related Activation-induced Cytokine, TRANCE, Tum

Anti -RANKL (Receptor Activator of Nuclear Factor kappa B Ligand, Receptor Activator of
NFkB Ligand, CD254, hRANKL2, hRANKL-2, Osteoclast Differentiation Factor, ODF,
Osteoprotegerin Ligand, OPGL, sOdf, SOFA, TNF-related Activation-induced Cytokine, TRANCE,
Tum

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
TNF-related activation-induced cytokine is a 35kD (predicted) type II transmembrane glycoprotein and member of the TNF cytokine family. Human TRANCE is 317aa in length and contains a 47aa cytoplasmic region, a 21aa transmembrane region, and a 249 extracellular domain (ECD), which contains two potential sites of N-linked glycosylation. Splicing variants produce three isoforms for human TRANCE. Isoform 1 is the standard form. In isoform 2, aa corresponding to 1-73 in isoform 1 are missing. In isoform 3, aa1-47 are missing. Human TRANCE ECD is 83% identical to mouse TRANCE ECD. TRANCE is expressed highest in the peripheral lymph nodes and weaker in the spleen, peripheral blood leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach, and thyroid. TRANCE plays a role in osteoclast differentiation and activation.
Catalog #R1075-13A
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 2ug/ml using human primary differentiated CD4+ Th2 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C. Stable for 12 months after receipt at 4°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG3
Clone No11n163
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to aa64-245 from human RANKL expressed in NS0 cells (AAC51762).
SpecificityRecognizes human RANKL. Species Crossreactivity: rmTRANCE; 100%, rhLIGHT; 25%. Does not cross-react with recombinant human 4-1BB Ligand, APRIL, BAFF, EDA, EDA-A2, Fas Ligand, GITR Ligand, OX40 Ligand, TNF-alpha, TRAIL, TWEAK, or VEGI.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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