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You are here:Home » Molecular Biology » MB-Growth Factors-RANK » sRANKL, Recombinant, Human (soluble RANK Ligand, Receptor Activator of NFkB Ligand)

sRANKL, Recombinant, Human (soluble RANK Ligand, Receptor Activator of NFkB Ligand)


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Catalog #R1076-03A
SourceRecombinant corresponding to human sRANKL expressed in E. coli.
Molecular Weight~20kD (corresponding to the full length of the TNF-like extracellular domain)
Biological ActivityED50 <10ng/ml. The biological activity was determined by measuring the dose-dependent stimulation of IL-8 production by isolated human PBMC’s. sRANKL, also known as ODF, TRANCE and TNF superfamily member 11, is a member of the TNF ligand superfamily. The receptor for sRANKL is RANK (Receptor Activator of NF-KappaB), a member of the TNFR family identified as a dendritic cell membrane protein. sRANKL influences dendritic cells’ ability to stimulate T-cells.
Endotoxin ~0.1ng/ug
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~20kD
Purity~98% (SDS-PAGE, HPLC)
ConcentrationNot determined
FormSupplied as a lyophilized powder in 5mM Tris, pH 7.6, and 50mM sodium chloride. Reconstitute with sterile dH2O to 0.1-1mg/ml.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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