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sRANKL, Recombinant, Mouse (soluble RANK Ligand, Receptor Activator of NFkB Ligand)
sRANKL, Recombinant, Mouse (soluble RANK Ligand, Receptor Activator of NFkB Ligand)
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| Catalog # | R1076-04A | | RANK Ligand occurs in 3 forms | cell-bound RANKL, which is expressed by osteoblast lineage cells, soluble RANKL, which is expressed by activated T lymphocytes, and a truncated ectodomain form derived from the cell-bound RANK Ligand, which is enzymatically processed by TACE. All three forms stimulate their specific receptor, RANK, which is located on osteoclastic and dendritic cells. RANK Ligand is critically involved in osnteoclastic function, and in the regulation of specific immunity. | | Biological Activity | Measured by its ability to induce osteoclast formation on murine RAW264.7 cells using a concentration of 5.0-10.0ng/ml. | | AA Sequence | PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O, aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 19.9kD | | Source | Recombinant, murine, E. coli | | Purity | ~95% Analysis by RP-HPLC; Reducing and non-reducing SDS-PAGE. | | Form | Supplied as a lyophilized powder. Reconstitute with sterile dH2O PBS to 0.1-1mg/ml, which can be further diluted into other aqueous solutions. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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