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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B IH FC

Rap1, also known as Krev-1 and smg p21, is a member of the Ras super family of GTPases closely related to Ras. Two known isoforms of Rap1 exists, Rap1A and Rap1B which share 95% identity (1-2). As a molecular switch, Rap1 cycles between two conformational states depending on whether GDP bound (active form) or GTP bound (inactive form). Rap1 associates with a subset of Ras effectors including Raf-1, B-Raf, phosphoinositide 3-kinase, Ral GEFs, and PLC (3). Although its function is still unclear, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion (4).
Catalog #	R1120-10B
Applications	Suitable for use in Flow Cytometry, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilutions	Flow Cytometry: 1:20
	Western Blot: 1:1000-5000
	Immunohistochemistry: 1:50-100
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Form	Supplied as a liquid.
Purity	Purified by immunoaffinity chromatography.
Immunogen	A synthetic peptide corresponding to residues near the N-terminus of human Rap1
Specificity	Recognizes human Rap1
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.