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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -Raptor, phosphorylated (Ser863) (Regulatory-associated Protein of mTOR, Raptor, P150 Target of Rapamycin (TOR)-scaffold Protein, RPTOR, KIAA1303)

Anti -Raptor, phosphorylated (Ser863) (Regulatory-associated Protein of mTOR, Raptor, P150
Target of Rapamycin (TOR)-scaffold Protein, RPTOR, KIAA1303)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
Catalog #R1170-02A
ApplicationsSuitable for use in ELISA and Dot Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Dot Blot: 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Ser863 of human Raptor (KLH).
SpecificityRecognizes human Raptor when phosphorylated at Ser863.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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