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Anti -Raptor, phosphorylated (Ser863) (Regulatory-associated Protein of mTOR, Raptor, P150 Target of Rapamycin (TOR)-scaffold Protein, RPTOR, KIAA1303)
Anti -Raptor, phosphorylated (Ser863) (Regulatory-associated Protein of mTOR, Raptor, P150
Target of Rapamycin (TOR)-scaffold Protein, RPTOR, KIAA1303)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E Gel |
|
| Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions. | | | Catalog # | R1170-02A | | Applications | Suitable for use in ELISA and Dot Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Dot Blot: 1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to amino acid residues surrounding er863 of human Raptor (KLH). | | Specificity | Recognizes human Raptor when phosphorylated at Ser863. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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