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Specifications

Clone Host Grade Applications Polyclonal Rabbit Serum IH

Ras is a G protein (specifically a small GTPase), a regulatory GTP hydrolase that cycles between two conformations – an activated or inactivated form, respectively RAS-GTP and RAS-GDP. The ras genes give rise to a family of related GTP-binding proteins that exhibit potent transforming potential. Mutational activation of Ras proteins promotes oncogenesis by disturbing a multitude of cellular processes, such as gene expression, cell cycle progression and cell proliferation, as well as cell survival, and cell migration. In mammalian cells, three ras genes encode four Ras isoforms (H-Ras, K-Ras4A, K-Ras4B and N-Ras) that are highly homologous but functionally distinct. Ras signaling is essential in development, cellular homeostasis and cancer. It also regulates cell growth, differentiation and apoptosis, as well as influencing processes such as cell migration and neuronal activity.
Catalog #	R1198-05B
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (paraffin): 1:50-1:100
	Optimal dilutions to be determined by the researcher.
Positive Control	Tonsil
Cellular Localization
	Cytoplasmic and cell membrane
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	Not determined
Form	Supplied as a liquid in 0.05% sodium azide.
Purity	Serum
Immunogen	Synthetic peptide corresponding to aa31-43 (EYDPTIEDSYRKQ) from L2 loop of human Ras.
Specificity	Recognizes human Ras. Species Crossreactivity: bovine, mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.