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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -RasGAP, NT (Ras GTPase Activating Protein, GAP)

Anti -RasGAP, NT (Ras GTPase Activating Protein, GAP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
Ras-GTPase-activating protein SH3-domain-binding protein; GAP binding protein; RasGAP-associated endoribonuclease G3BP: This protein is one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Catalog #R1198-13N
ApplicationsSuitable for use in Immunoprecipitation and Western Blot. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:3000 for detection of the full-length protein; 1:100-1:300 for detection of the caspase-generated fragments.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant fusion protein corresponding to aa158-455 (fragment N2) of human RasGAP (Ras-specific GTPase-activating protein).
SpecificityRecognizes human full-length RasGAP as well as the N-terminal fragment (that comprises SH2 and SH3 domains) generated by caspase cleavage (fragments N and N2). Does not cross-react with other GAP proteins. Species crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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