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Abs to GTPase, Rab, Ras, Rho Proteins
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Anti -RasGRP4 (RAS Guanyl Releasing Protein 4, RAS Guanyl-releasing Protein 4) (Azide Free)
Anti -RasGRP4 (RAS Guanyl Releasing Protein 4, RAS Guanyl-releasing Protein 4) (Azide
Free)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq] | | | Catalog # | R1198-18A | | Applications | Suitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1.5ug/ml | | Western Blot: 1:500-1:1,000 | | ELISA: 1ug/ml-3ng/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 11C668 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant protein corresponding to aa574-674 of human RASGRP4. | | Specificity | Recognizes human RASGRP4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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