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You are here:Home » Antibodies » Abs to GTPase, Rab, Ras, Rho Proteins » Anti -Ras, R (R-Ras, RRAS, Oncogene RRAS, p23, Ras-related Protein, Ras-related Protein R-Ras, Related RAS Viral (r-Ras) Oncogene Homolog)

Anti -Ras, R (R-Ras, RRAS, Oncogene RRAS, p23, Ras-related Protein, Ras-related Protein
R-Ras, Related RAS Viral (r-Ras) Oncogene Homolog)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH
R-Ras is a member of the Ras superfamily of GTPases. Ras proteins function as signaling focal points that are activated by convergent signaling pathways intiated by extracellular stimuli (reviewed in Mitin et al, 2005). Activated Ras proteins in turn regulate a diversity of downstream cytoplasmic signaling cascades. Many members of the Ras superfamily are implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The Ras superfamily of proteins includes over 150 small GTPases (distinguished from the large, heterotrimeric GTPases, the G-proteins). It comprises six subfamilies, the Ras, Rho, Ran, Rab, Arf, and Kir:Rem:Rad subfamilies. They exhibit considerable overall aa identities, especially in the regions interacting with the guanine nucleotide exchange factors that catalyze their activation. Recognizes R-Ras; human R-Ras is a 218aa protein.
Catalog #R1200-10B
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000
Immunoprecipitation: 1:50-1:200
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive ControlHeart colon spleen, CA cell lines
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa11-31 (RGRPRGGGPGPRDPPPGETHK) of human R-Ras, GenBank no. gi|5454028|ref|NP_006261.1|.
SpecificityRecognizes human R-Ras. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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