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You are here:Home » Antibodies » Abs to Retinoblastoma Proteins » Anti -RBL2, CT (Retinoblastoma-like Protein 2, Retinoblastoma-related Protein 2, RBR-2, PRB2, 130kD Retinoblastoma-associated Protein, p130, RB2)

Anti -RBL2, CT (Retinoblastoma-like Protein 2, Retinoblastoma-related Protein 2, RBR-2,
PRB2, 130kD Retinoblastoma-associated Protein, p130, RB2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B IP IH
RBL2 is a key regulator of entry into cell division. The protein is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. It controls histone H4 'Lys-20' trimethylation. It probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters.
Catalog #R1200-50J
ApplicationsSuitable for use in Western Blot, ELISA, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:2000
ELISA: 1:5000-1:20,000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.02M potassium phosphate, 0.15M sodium chloride, pH 7.2, 0.01% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to human RBL2 at C-terminal (KLH).
SpecificityRecognizes human RBL2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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