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Relaxin 3, Recombinant, Human (H3 Relaxin, Insulin-Like Peptide-7, INSL7)
Relaxin 3, Recombinant, Human (H3 Relaxin, Insulin-Like Peptide-7, INSL7)
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| Relaxin-3 (H3 relaxin, Insulin-like peptide-7, INSL7) is a secreted protein structurally related to insulin, which is expressed primarily in the brain and central nervous system. Relaxin-3 has been identified as the ligand for the GPCR135 receptor, previously known as “somatostatin-like” or “angiotensin-like” peptide receptor, and also binds specifically to the LGR7 receptor, previously identified as an “orphan” G protein coupled receptor. Signaling by Relaxin-3 through its target receptors is, most likely, part of a CNS processing system, activated in response to signaling by neuropeptides and other factors. Intracerebroventricular injections of Relaxin-3 have been shown to cause a significant increase of food intake and body weight in Wistar rats. Recombinant Relaxin-3 is a 5.5kD disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 27 amino acid B-chain. | | | Catalog # | R1425-20 | | Source | E. coli | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile buffer, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Biological Activity | Data Not Available. | | Country of Origin | USA | | Source | E. coli | | Purity | 98% by SDS-PAGE and HPLC analyses. | | Concentration | As reported | | Form | Supplied as a lyophilized powder. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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