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You are here:Home » Antibodies » Abs to Angiotensin, Angiotensinogen » Anti -Renin-1 (Angiotensinogenase, Kidney Renin)

Anti -Renin-1 (Angiotensinogenase, Kidney Renin)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IP
Mouse Renin is a secreted, 42-47 kD glycosylated member of the peptidase A1 family. It is an aspartyl protease that cleaves angiotensinogen to form angiotensin I. In mouse, there are two genes that code for Renin. One is in the submandibular gland and the other is in the kidney. The two mature Renin molecules are 95% amino acid (aa) identical. Renal Renin (Renin-1) is synthesized as a 381 aa proform (aa 22-402). In the kidney, pro-Renin is proteolytically cleaved after Thr71 to generate a mature enzyme. Mouse pro-Renin shares 70% and 85% aa sequence identity with human and rat pro-Renin, respectively.
Catalog #R1460-40
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-0.2ug/ml
ELISA: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceMouse
ConcentrationAs reported
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
PurityPurified by mouse Renin-1 affinity chromatography.
ImmunogenNS0-derived recombinant mouse Renin-1 (aa22-402) Accession # P06281
SpecificityRecognizes mouse Renin-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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