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You are here:Home » Antibodies » Abs to Angiotensin, Angiotensinogen » Anti -Renin, CT (Angiotensinogenase, RATRENAA, Ren1, RENAA, Renin)

Anti -Renin, CT (Angiotensinogenase, RATRENAA, Ren1, RENAA, Renin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Renin is an aspartyl protease that cleaves angiotensinogen a-glycoprotein to form the decapeptide angiotensin I (ANG I). ANG I is converted into ANG II that induces various endocrine effects including regulation of blood pressure in mammals. Thus, rennin is the rate- limiting step in rennin-angiotensin system (RAS) and its expression is tightly regulated. Tigerstedt and Bergmann first identified renin in 1898 and its secretion was attributed to kidney only. However, recent studies demonstrate that heart, brain, mast cells and other tissues and cells are capable of local renin production. In addition, mice with mutant renin genes were found to have low arterial blood pressure, reduced glomerular filtration rate, and low aldosterone levels.
Catalog #R1475-10B
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal region of human Renin.
SpecificityEcognizes human Renin. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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