Anti -Resistin (RETN, RETN1, RSTN, Adipose Tissue-Specific Secretory Factor, ADSF, FIZZ3,
Cysteine-rich Secreted Protein A12-alpha-like 2, Cysteine-Rich Secreted Protein FIZZ3,
C/EBP-epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein, HXCP1, RSTN
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| RELM:FIZZ family of proteins are Cysteine-rich proteins consist of a highly conserved C-terminal cysteine rich domain and play a vital role in regulation of adipogenesis and insulin resistance. Resistin, a human homolog of mouse resistin, is a novel member of this family. It is a 12kD adipokine which is produced by both brown and white adipose tissue and is mainly secreted by adipocytes. Its levels are down-regulated by insulin and have been shown to be elevated during Type 2 diabetes, indicating a critical role in regulating adipogenesis and insulin resistance. It promotes aortic smooth muscle cell proliferation through activation of ERK1:2 and PI3:Akt signaling pathways. It is expressed in macrophages and functions as a pro-inflammatory cytokine by up-regulating IL-6 and activating NF-kappaB signaling pathway. Its expression is regulated by numerous factors which include PPAR-alpha, Insulin, Growth and gonadal hormones, TNF-alpha, Endothelin-1 and certain pro-inflammatory cytokines like IL-6. | | | Catalog # | R1585-02L | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa94-102 [AGMDWTGAR] of human Resistin. | | Specificity | Recognizes human Resistin. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Cysteine-Rich Secreted Protein A12-alpha-Like 2, Found in Inflammatory Zone, MGC126603, MGC126609 |
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Download Specifications for Anti -Resistin (RETN, RETN1, RSTN, Adipose Tissue-Specific Secretory Factor, ADSF, FIZZ3, Cysteine-rich Secreted Protein A12-alpha-like 2, Cysteine-Rich Secreted Protein FIZZ3, C/EBP-epsilon-Regulated Myeloid-Specific Secreted Cysteine-Rich Protein, HXCP1, RSTN |
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